Camila Orellana
- Position
- Assistant Professor
- Academic unit
- Department of Chemical Engineering and Bioprocesses, School of Engineering, UC
- Institute of Biological and Medical Engineering, UC
- Lines of Research
- Biotechnology and Fermentations (production of high-value compounds, metabolic engineering, optimization of medium and culture operating conditions).
- Mammalian cell culture
- Systems Biology
- Biopharmaceutical production
- Production of biodegradable bioplastics
- Summary
Dr. Camila Orellana is Assistant Professor at the Department of Chemical Engineering and Bioprocesses and at the Institute of Biological and Medical Engineering (IIBM) of the Pontificia Universidad Católica de Chile.
She is a Civil Engineer in Biotechnology with a Master in Engineering Sciences mention in Chemistry from the University of Chile. She completed her PhD (2016) at the Australian Institute for Bioengineering and Nanotechnology at the University of Queensland, where she also conducted postdoctoral research until 2019. He joined in 2020 to the UC School of Engineering and in 2024 to the IIBM.
Dr. Camila Orellana studies the production of recombinant proteins for therapeutic purposes (biopharmaceuticals) from mammalian cell culture. She uses systems biology (omics) and genome editing (genetic engineering) to design cells that are used for the bioproduction of potent complex drugs, optimizing them to make them more efficiently.
- Diploma in Women and Leadership (2024), Pontificia Universidad Católica de Chile
- Diploma in University Teaching (2022), Pontificia Universidad Católica de Chile
- Ph.D. in Systems Biology, The University of Queensland
- M.Sc. in Engineering Sciences, mention in Chemistry, Universidad de Chile.
- Civil Engineer in Biotechnology, Universidad de Chile
Fondecyt Initiation 2024. Principal Investigator
"Developing death-resistant CHO cell lines as a platform for biopharmaceutical production"
Fondecyt Regular 2024. Co-Investigator
"Redefining Bioproduction: Customized CHO Cell Platforms for Streamlined Continuous Manufacturing"
Open Seed Fund Applied 2023. Pontificia Universidad Católica de Chile. Principal Investigator. "Media Optimization for Bioplastic Production by Halomonas species".
Open Seed Fund 2020. Pontificia Universidad Católica de Chile. Principal Investigator.
"Exploring Halomonas species as a microbial platform for bioplastic production".
Deantas-Jahn C., Mendoza S., Licona-Cassani, C., Orellana, CSaa, P.A. Metabolic modeling of Halomonas campaniensis improves polyhydroxybutyrate production under nitrogen limitation. Applied Microbiology and Biotechnology, 2024, 108:310. doi:10.1007/s00253-024-13111-8.
Orellana C.A.Martinez V.S., MacDonald M., Henry M.N., Gillard M., Gray P.P., Nielsen L.K., Mahler S., Marcellin E. Minireview: 'Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells. Biotechnology and Bioengineering, 2021, 118 (1): 481-490. doi:10.1002/bit.27548.
Orellana C.A., Zaragoza N.E., Licona-Cassani C., Palfreyman R.W., Cowie N., Moonen G.A., Moutafis G., Power J., Nielsen L.K. and Marcellin E. Time-course transcriptomics reveals that amino acids catabolism plays a key role in toxinogenesis and morphology in Clostridium tetani. Journal of Industrial Microbiology & Biotechnology, 2020, 47:1059-1073.
Henry M.N., MacDonald M., Orellana C.A.Gray P.P., Gillard M., Bakey K., Nielsen L.K., Marcellin E., Mahler S., Martinez V.S. Attenuating apoptosis in Chinese Hamster ovary cells for improved biopharmaceutical production. Biotechnology and Bioengineering, 2020, 117 (4): 1187-1203.
Zaragoza N.E., Orellana C.A..Moonen G.A., Moutafis G., Marcellin E. Vaccine production to protect animals against Pathogenic Clostridia. Toxins (Basel), 2019, 11 (9). pii: E525.1.
Cruz-Morales P., Orellana C.A., Orellana C. A.., Moutafis G., Moonen G., Rincon G., Nielsen L.K., Marcellin E. Revisiting the evolution and taxonomy of Clostridia, a phylogenomic update. Genome Biology and Evolution, 2019, 11 (7): 2035-2044.
Orellana, C.A., Marcellin, E., Palfreyman, R.W., Munro, T.P., Gray, P.P. and Nielsen, L.K. RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells. Biotechnology Journal, 2018, 13 (3): e1700231.
Orellana C.A., Marcellin E., Gray P.P, Nielsen L.K. Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells. Biotechnology and Bioengineering, 2017, 114 (8): 1825-1836.
de Oliveira Dal'Molin C.G., Orellana C., Gebbie L., Steen J., Hodson M.P., Chrysanthopoulos P., Plan M.R., McQualter R., Palfreyman R.W., Nielsen L.K. Metabolic Reconstruction of Setaria italica: A Systems Biology Approach for Integrating Tissue-Specific Omics and Pathway Analysis of Bioenergy Grasses. Frontiers in Plant Science, 2016, 7: 1138.
Hefzi, H., Ang, K.S., Hanscho, M., Bordbar, A., Ruckerbauer, D., Lakshmanan, M., Orellana, C.A.Baycin-Hizal, D., Huang, H., Ley, D., Martinez, V.S., Kyriakopoulos, S., Jimenez, N.E., Zielinski, D.C., Quek, L.E., Wulff, T., Arnsdorf, J., Li, S., Lee, J.S., Paglia, G., Loira, N., Spahn, P.N., Pedersen, L.E., Gutierrez, J.M., Lund, A.M., Nagarajan, H., Thomas, A., Abdel-Haleem, A.M., Zanghellini, J., Kildegaard, H.F., Voldborg, B.G., Gerdtzen, Z.P., Betenbaugh, M.J., Palsson, B.O., Andersen, M.R., Nielsen, L.K., Borth, N., Lee, D.Y., Lewis, N.E. A consensus genome-scale reconstruction of CHO cell metabolism for improved biotherapeutic protein production. Cell Systems, 2016, 3 (5): 434-443.e8.
Swainston, N., Smallbone, K., Hefzi, H., Dobson, P.D., Brewer, J., Hanscho, M., Zielinski, D.C., Ang, K.S., Gardiner, N.J., Gutierrez, J.M., Kyriakopoulos, S., Lakshmanan, M., Li, S., Liu, J.K., Martinez, V.S., Orellana, C.A., Quek, L.E., Thomas, A., Zanghellini, J., Borth, N., Lee, D.Y., Nielsen, L.K., Kell, D.B., Lewis, N.E., Mendes, P. Recon 2.2: from reconstruction to model of human metabolism. Metabolomics, 2016, 12: 1-7.
Orellana C. A., Marcellin E., Schulz B.L., Nouwens A.S., Gray P.P, Nielsen L.K. High antibody- producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis. Journal of Proteome Research, 2015, 14 (2): 609-618.
Orellana C.A., Shene C., Asenjo J.A. Mathematical Modeling of Elution Curves for a Protein Mixture in Ion Exchange Chromatography Applied to High Protein Concentration. Biotechnology and Bioengineering, 2009, 104 (3): 572-581.